“Choline has several important functions:  it is a source of methyl groups needed to make S-adenosylmethionine, it is a part of the neurotransmitter acetylcholine, and it is a part of the predominant phospholipids in membranes (phosphatidylcholine and sphingomyelin).  Betaine, formed from choline, is an important osmolyte in the kidney glomerulus and helps with the reabsorption of water from the kidney tubule.  Although they represent a smaller proportion of the total choline pool, important metabolites of choline include platelet-activating factor, choline plasmalogens, lysophosphatidylcholine, phosphocholine, and glycerophosphocholine” [1].  

 

Regarding Choline, WebMD reports, “Athletes use it for bodybuilding and delaying fatigue in endurance sports” [2].  Low levels of Choline have been found in endurance athletes and supplementation may decrease fatigue during exercise [3].